NFL 2025 Week 6 Picks, Props, Parlays And Preview

The NFL 2025 Week 6 picks and schedule features just two division games and the Giants kicked it off Thursday with a big ‘Dog winner over NFC East rival and Super Bowl champions Eagles, 34-17. The Steelers and Browns battle Sunday in the other division game in Week 6 with the Sunday Night Football feature Lions and Chiefs in Kansas City drawing major wager action.

Check out my NFL 2025 Week 6 tips, totals, teasers and trends that includes a game total on the Lions-Chiefs game, and additional information you can bet on.

My NFL 2025 Week 6 picks, parlays and props are added below with initial post and details at OSGA. More player prop winners in Week 5 followed Week 4 player props that went 7-0 overall, and the last three weeks player props posted on this site and OSGA are 11-0.

Let’s shoot for better results and more winners on our NFL 2025 Week 6 picks and opinions and perhaps add bonus cash with a winning parlay.

The NFL weather is something to monitor as well with potential rain and wind in Kansas City affecting our initial Lions-Chiefs totals pick. Also, likely rain in Baltimore for Rams-Ravens with potential winds gusting to 30 mph.

NFL Week 6 Odds

Betting lines and NFL odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Point spread on favorites plus game totals, and division games in bold.

– Philadelphia (-7.5) at New York Giants, 40.5 (Thursday)
– Denver (-7) vs. New York Jets, 43 (London)
– Cleveland at Pittsburgh (-6), 38.5
– Arizona at Indianapolis (-7.5), 46.5
– Los Angeles Rams (-7.5) at Baltimore, 44.5
– Seattle (-1) at Jacksonville, 47.5
– Dallas (-3 / 3.5) at Carolina, 49.5
– Los Angeles Chargers (-4) at Miami, 43
– New England (-3.5) at New Orleans, 45.5
– Tennessee at Las Vegas (-4), 42
– San Francisco at Tampa Bay (-3), 47
– Cincinnati at Green Bay (-14.5), 44.5
– Detroit at Kansas City (-2.5), 52.5  (Sunday Night)
– Buffalo (-4.5) at Atlanta, 49.5 (Monday)
– Chicago at Washington (-4.5), 50 (Monday)

Notable line moves from last week’s lookahead lines includes Colts from -3.5 to -7.5, Raiders -6.5 to -4 and Bills -5.5 to -3.5 or 4.

Check out the weekly injury reports, and note the need to review before posting our late weekend picks, props and parlays.

Picking NFL side winners late week is difficult, but we hit 57% ATS over a 7-year run through 2023 at OSGA picking only NFL underdogs. We continue to chip-in for news and entertainment purposes as a proven point spread prognosticator and professional shooting for green on the gridiron.

Player Props And NFL 2025 Week 6 Picks

Be sure to review the NFL injury reports as teams like the Ravens and now Seahawks are decimated on defense.

Picks: Panthers
Opinions: Seahawks, Chargers, Falcons

Any additions Sunday and Monday. More player props below.

3-team parlay: Seahawks, Chargers, Lions/Chiefs ‘over’
2-team ‘Dog parlay: Panthers, Falcons

Straight Up Winners in Competitvely Lined Games

Picking the outright winner in competitively-lined NFL games (6-points or less) has produced a 53-4 ATS record this season, and continues a strong result historically. So if you like underdogs, like we did when posting 57% ATS winners over 7 years at OSGA from 2017-2023, then a portion of your bet should be on the moneyline.

See game notes and stats on select NFL 2025 Week 6 picks and games at OSGA.

Any additions Sunday and Monday. More player props below and consider additions for Sunday night and Monday night football. Player props 11-0 last three weeks with picks, opinions, recommendations.

Panthers RB Rico Dowdle – over 72.5 rushing yards. Notes at OSGA.

Player prop winner and 12-0 player prop picks, opinions and recommendations NFL Week2 3-6. Posted here after game from initial writeup and coverage at Off Shore Gaming Association.

Panthers RB Rico Dowdle – The former Cowboys running back will start with Hubbard sidelined (calf), and he’ll be running hard and getting chances against a Cowboys defense allowing an average of 29 rush attempts per game and 127 yards per game. Dowdle broke out last week with 23 rushes for 206 yards and 1 TD in the Panthers come-from-behind win over Miami, 27-24. Panthers clueless QB Bryce Young continues to prove he’s not an NFL caliber starting quarterback, and you can see some of his inefficient stats and matchup potential against the Cowboys zone defense (81%, 4th highest). Every quarterback the Cowboys defense has faced this season has been QB7 or better in weekly scoring, and that’s against a bunch of bumbling bro’s who are mostly inefficient – Russell Wilson, Justin Fields, Caleb Williams. Young has few excuses again, but we’re counting on more running game success with Dowdle leading the way.

Additional prop bet above on Chargers team total ‘over’ 24 points.