2025 NFL Week 6 Tips, Totals, Teasers And Trends

The NFL season continues and no undefeated teams remaining after both the Bills and Eagles were upset in NFL Week 5 losses. The Eagles lost again as a big road favorite to the Giants to kickoff our 2025 NFL Week 6 Tips, Totals, Teasers and Trends with New York dominating the point of attack outrushing the Eagles 172-72 and rookie RB Cam Skattebo running for 3 touchdowns. Now we tackle more games including the Sunday Night Football feature Detroit at Kansas City, and a big totals move to note as part of our weekly totals picks.

Be sure to check out my NFL Week 6 picks, props and parlays as posted over the weekend. Player props are 11-0 the past three weeks on picks, opinions and betting recommendations with Eagles RB Saquon Barkley 4-0 for us on receiving props in Week 4 and Week 5.

NFL Week 6 Odds

Betting lines and NFL odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Point spread on favorites plus game totals, and division games in bold for 2025 NFL Week 6 tips.

– Philadelphia (-7.5) at New York Giants, 42 (Giants win 34-17)
– Denver (-7) vs. New York Jets, 43.5 (London)
– Cleveland at Pittsburgh (-5.5), 38.5
– Arizona at Indianapolis (-7), 47.5
– Los Angeles Rams (-7) at Baltimore, 44.5
– Seattle (-1.5) at Jacksonville, 47.5
– Dallas (-3) at Carolina, 49.5
– Los Angeles Chargers (-4.5) at Miami, 43.5
– New England (-3.5) at New Orleans, 45.5
– Tennessee at Las Vegas (-4.5), 41.5
– San Francisco at Tampa Bay (-3.5), 47.5
– Cincinnati at Green Bay (-14.5), 44.5
– Detroit at Kansas City (-2.5), 52.5  (Sunday Night)
– Buffalo (-4.5) at Atlanta, 49.5 (Monday)
– Chicago at Washington (-4.5), 49.5 (Monday)

Notable line moves from last week’s lookahead lines includes Colts from -3.5 to -6.5 to -7, Raiders -6.5 to -4.5 and Bills -5.5 to -3.5 to -4.5.

Scoring is up to 47.1 points per game this season after NFL Week 5 averaged 49.3 points per game following the Jaguars 31-28 come-from-behind stumbling, bumbling touchdown and win over the Chiefs Monday night.

Game Totals 

Picks

Seahawks-Jaguars – Over (released 45, now 47.5)
Lions-Chiefs – Over (released 50.5, now 5

Check back Sunday for any additions, opinions.

Teasers

Seahawks, Saints, Lions, Falcons, Rams (following injury check, Ravens ravaged by injuries, QB Jackson).