NFL 2025 Week 5 Picks, Props And Preview

The NFL 2025 Week 5 picks and schedule features just two division games and the 49ers outlasted the Rams 26-23 in overtime Thursday night to kickoff October and the Week 5 schedule. The Vikings play an international game for the second week in a row, this time in London vs. the Browns. I chip-in the matchups, odds and insight below with picks, parlays and props after going 4-0  on our Week 4 player props plus additional 3-0 on props opinions and recommendations. The Week 4 picks and opinions went 1-1 and the weeks ahead will include more stats updates including rushing guidelines to assist you in your matchup analysis.

Check out my NFL Week 5 tips, totals and teasers and additional updates on scoring, injuries and information you can bet on. The NFL weather looks fine into Sunday action.

NFL Week 5 Odds

Betting lines and NFL odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Point spread on favorites plus game totals, and division games in bold for NFL 2025 Week 5 picks and odds.

– San Francisco at Los Angeles Rams (-8.5), 43.5 Thursday (49ers win 26-23 in overtime)
– Minnesota (-3.5) vs. Cleveland, 36 – London
– Miami (-1) at Carolina, 44.5
– Dallas (-2.5) at NY Jets, 47.5
– Las Vegas at Indianapolis (-7), 48
– Denver at Philadelphia (-3.5), 43.5
– NY Giants at New Orleans (-2), 42
– Houston (-2) at Baltimore, 40.5
– Tennessee at Arizona (-7.5), 42
– Tampa Bay at Seattle (-3.5), 44.5
– Detroit (-10.5) at Cincinnati, 49.5
– Washington at LA Chargers (-2.5 / 3), 47
– New England at Buffalo (-9), 48 – Sunday night
– Kansas City (-3.5) at Jacksonville, 45.5 – Monday night

Notable line moves this week with the favorite flipping to New Orleans and Houston as favorites, and Ravens QB Lamar Jackson (hamstring) likely out having missed practice Wed-Fri. Full Week 5 NFL injury reports to monitor.

Picking NFL side winners late week is difficult, but we hit 57% ATS over a 7-year run through 2023 at OSGA picking only NFL underdogs. We continue to chip-in for news and entertainment purposes as a proven point spread prognosticator and professional shooting for green on the gridiron.

Player Props And NFL 2025 Week 5 Picks

Picks: Jets
Opinions: Cardinals, Chargers

Any additions Sunday and Monday. More player props below.

3-team parlay: Cardinals, Chargers, Bills
2-team ‘Dog parlay: Jets, Jaguars

See Jets-Cowboys analysis at OSGA.

Please note that player props odds, yardages and promotions vary more greatly at leading online sportsbooks. Do your best to shop various props, odds and options. Fairways Forecast was 4-0 on official Week 4 player props (plus 3-0 opinions and recommendations), and 2-0 in Week 3.

Player Props

Eagles RB Saquon Barkley: Over 16.5 receiving yards (up slightly late week).

Again, add over 2.5 receptions for 1/2 unit, or 3.5 at plus money or reduced juice.

Analysis, stats and any additional player props ahead of Sunday at OSGA.