College Football Week 12 Picks And Top 25 Matchups

The final few weeks of the regular season includes some key Top 25 match-ups and big rivalry games. No significant college football Week 12 picks of interest in the Top 25 match-ups, but I chip-in some other picks and thoughts with information you can bet on.

Last week a few more winners, and unfortunate losers including on NC State (+2.5) losing by a field goal and blowing many chances to win against deficient defense of Wake Forest in a 45-42 defeat. That sets of the Week 12 showdown for the ACC Atlantic Division title and spot in the ACC Championship game between Wake Forest and Clemson (-4.5) in Death Valley. Clemson has taken money with 87% of the spread money at WynnBet.

The push towards the College Football Playoff. continues with some notable games and Top 25 match-ups this week. Major stakes and rivalry games remain, and the pressure mounts on the top teams. More bonus winners recently involving Top 25 teams (Purdue over Michigan State), and we’ve added more below involving Top 25 teams. But our focus here each week for interest and the biggest bet games is on the two teams in Top 25 match-ups.

College Football Playoff Rankings

The third College Football Playoff (CFB) rankings came out Nov. 16, and those rankings differ from the AP Top 25, where Georgia has been the unanimous top-ranked team for five straight weeks.

The power conference championship games are Dec. 4-5.

The four teams selected to the 2021-22 College Football Playoff will be announced during the last top 25 rankings show at 12 p.m. ET on Sunday, Dec. 5 on ESPN. New Year’s Six matchups will also be revealed at that time.

As you evaluate the Week 12 college football card and Top 25 match-ups and teams, review my recent stats update on balanced and efficient offensive teams that may assist you in your handicapping and selections.

College Football Week 12 Picks

Week 12 AP Top 25 Match-ups 

Saturday, Nov. 20

College Football Week 12 PicksNo. 7 Michigan State at No. 5 Ohio State / 12:00 p.m. ET / ABC
No. 21 Arkansas at No. 2 Alabama / 3:30 p.m. ET / CBS
No. 4 Oregon at No. 24 Utah / 7:30 p.m. ET / ABC

  • WynnBet reports the two most bet college football games on the entire card this week are: (spread, moneyline, totals combined)
  • Michigan State at Ohio State -18.5 (52% spread money Ohio State)
  • Arkansas at Alabama -21 (85% spread money Alabama)

College Football Week 12 Picks and Top 25 Teams

Review full game analysis on each game at

Michigan State at Ohio State
Line: Ohio State -18.5 and Total 68.5 WynnBet

Lean: Ohio State

Arkansas at Alabama
Line: Alabama -21 and Total 58.5 at Caesars Sportsbook

Opinion: Arkansas plus the points

Oregon at Utah
Line: Utah -3.5 and Total 59 at Circa Sports

Opinion: Oregon plus the points and moneyline

Upset picks – Top 25 Teams

Oregon State (+3.5) vs Arizona State

Iowa State (+3.5) at Oklahoma

Baylor (+1) at Kansas State

SMU (+11) at Cincinnati

Also, UCLA (-3) over USC in crosstown rivalry game is a bet. And remember to tune into The Big Game with Cal at Stanford (+2.5).

Check back next week for the biggest rivalry weekend of the season including:

  • Ohio State at Michigan (Big Game)
  • Alabama at Auburn (The Iron Bowl)
  • Oklahoma at Oklahoma State (Bedlam)
  • Oregon at Oregon State (formerly Civil War)
  • Wisconsin at Minnesota (Paul Bunyan’s Axe)
  • Ole Miss at Mississippi State (Egg Bowl)
  • Iowa at Nebraska (Heroes Game)
  • North Carolina at North Carolina State
Author: FairwayJay is a leading national sports betting analyst, writer, handicapper and sports betting insider providing insight and information you can bet on for nearly two decades from Las Vegas. He chips in additional sports betting coverage and reporting on industry news and events for leading media and sports betting sites and companies. Follow him on X (Twitter): @FairwayJay