College Football 2025 Week 4 Top 25 Preview And Picks

College football 2025 Week 4 features three Top 25 match-ups, and I chip-in some insight, picks and information you can bet on for the biggest games and those generating the most betting action. That includes in the Big Ten with Illinois at Indiana and SEC where Auburn visits Oklahoma. A key Big 12 Top 25 matchup includes Texas Tech at Utah.

Check out my college football Top 25 update at OSGA plus analysis of picks and opinions, which went 9-2 ATS in Week 2 and Week 3 Top 25 games.

Top 5 teams Ohio State, Penn State and Georgia have a bye in college football 2025 Week 4, along with Texas A&M, Iowa State and Alabama in the top 15.

I do not tout or sell picks for companies, but my history as a proven sports handicapper has been documented in the past as a top of the leaderboard sports betting analyst while also contributing and reporting on sports and college football for Forbes, FanDuel and other media outlets in the sports betting space.

Top 25 Games and Week 4 Lines

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites plus game totals as of Thursday. All times ET.

Check back by Friday each week as we add Picks and Opinions with select analysis, stats and information you can bet on.

Saturday, Sept. 20

• No. 1 Ohio State | Bye
• No. 2 Penn State | Bye
• No. 3 LSU (-39.5) vs. SE Louisiana , 51.5 | 7:30 p.m. | SEC Network
• No. 4 Miami (-7.5) vs. Florida, 50.5 | 7:30 p.m. | CW Network
• No. 5 Georgia | Bye
• No. 6 Oregon (-35) vs. Oregon State, 55.5 | 3:30 p.m. | Big Ten Network
• No. 7 Florida State (-46) vs. Kent State, 56 | 3 p.m. | ACC Network
• No. 8 Texas (-39.5 ) vs. Sam Houston St, 51.5 | 8 p.m. ESPN+
• No. 9 Illinois at No. 19 Indiana (-6) 52.5 | 7:30 p.m. | NBC
• No. 10 Texas A&M | Bye
• No. 11 Oklahoma (-6.5) vs. No. 22 Auburn, 48 | 12 p.m. | ABC
• No. 12 Iowa State | Bye
• No. 13 Ole Miss (-13) vs. Tulane, 61 | 3:30 p.m. | ESPN
• No. 14 Alabama | Bye
• No. 15 Tennessee (-40) vs. UAB, 69 | 12:45 p.m. | SEC Network
• No. 16 Utah (-3) vs. No. 17 Texas Tech, 58 | 12 p.m. | FOX
• No. 18 Georgia Tech (-24) vs. Temple, 51 | 4:30 p.m. | CW Network
• No. 20 Vanderbilt (-27) vs. Georgia State, 53 | 4 p.m. | ESPN+/SECN+
• No. 21 Michigan (-2) at Nebraska, 46 | 3:30 p.m. | CBS
• No. 23 Missouri (-10.5) vs. South Carolina, 48 | 7 p.m. | ESPN
• No. 24 Notre Dame (-25.5) vs. Purdue, 54 | 3:30 p.m. | NBC
• No. 25 USC (-18.5) vs. Michigan State, 56 | 11 p.m. | FOX

Other noteable games on Sat., Sept. 20

– Syracuse at Clemson (-17), 55.5
– NC State at Duke (-3), 59
– West Virginia at Kansas (-13.5), 56
– Boise State (-10) at Air Force, 51
– Arizona State at Baylor (-2.5), 59.5
– Washington (-19.5) at Washington State, 53.5
– Wyoming at Colorado (-13), 44

NCAA Football Week 4 Picks

Updates and select analysis to follow with ATS Picks and Opinions unless noted ahead of Sat. games.

See picks and analysis of college football 2025 Week 4 Top 25 at Off Shore Gaming Association. Check back ahead of Saturday kickoff for any additional updates and line adjustments including Michigan (-2.5 to -1) at Nebraska and Illinois at Indiana (-6 to -6.5).

You can bet on it.