College Football 2025 Week 2 Top 25 Preview And Picks

Week 2 of the college football season often sees some significant line adjustments based on Week 1 results. This season college football 2025 Week 2 also has more shuffling in the Top 25 following three top 10 matchups in Week 1 that were closer one-score results. Major SEC and ACC favorites and College Football Playoff contenders Texas and Clemson went down in defeat along with last year’s national championship game participant Notre Dame.

So last year’s national champion Ohio State is back on top at No. 1 following a 14-7 win over Texas, who received 25 first place votes in the AP Poll last week, and now drop to No. 7 with zero votes. The Buckeyes received 55 first place votes with fellow Big Ten bulldog Penn State No. 2 and seven votes for the top spot. Mark your calendar for the major showdown in two months when Penn State visits Columbus to tackle Ohio State on Nov. 1.

Review the college football stability score ratings as the betting lines adjust early season including college football 2025 Week 2 odds and matchups as you compare openers to current lines with selected picks and bets below. I also review weekly NCAA football boxscore data and note stats and rushing edges, balanced and efficient offenses and key plays plus misleading finals and boxscore data.

Top 25 Games and Week 2 Lines

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Point spread on favorites plus game totals taken from Monday openers. All times ET.

Check back by Friday each week as we add Picks and Opinions with select analysis, stats and information you can bet on.

Sat., Sept. 6.

• Grambling State at No. 1 Ohio State (N/A) | 12:30 pm Big Ten Network
• Florida Intl at No. 2 Penn State (-42), 54.5 | 12 pm Big Ten Network
• Louisiana Tech at No. 3 LSU (-38), 52.5 | 4:30 pm ESPN+/SEC
• Austin Peay at No. 4 Georgia (N/A) | 12:30 pm ESPN+/SEC
• Bethune Cookman at No. 5 Miami (N/A) 4:30 p.m. FOX
• Oklahoma State at No. 6 Oregon (-28), 59 | 12:30 pm Big Ten Network
• San Jose State at No. 7 Texas (-36.5), 51  | 3:30 pm ABC or ESPN
• Troy at No. 8 Clemson (-33), 51.5 | 12:30 p.m. ACC Network
• No. 9 Notre Dame | Bye
• South Carolina State at No. 10 South Carolina (N/A) | 4  pm ESPN+/SEC
• No. 11 Illinois (-3) at Duke, 49.5 | 12 pm ABC or ESPN
• No. 12 Arizona State (-7) at Mississippi State, 59 | 4:30 pm ESPN2
• South Florida at No. 13 Florida (-17), 54.5 | 1:15 pm SEC Network
• East Texas A&M at No. 14 Florida State (N/A) | 9 am ACC Network
• No. 15 Michigan at No. 18 Oklahoma (-5), 46.5 | 4:30 p.m. ABC
• Iowa at No. 16 Iowa State (-3), 41.5 | 12 pm FOX
• Baylor at No. 17 SMU (-3), 65 | 12 pm CW Network
• Utah State at No. 19 Texas A&M (-29.5), 55.5 | 12:45 pm SEC Network
• No. 20 Ole Miss (-10) at Kentucky, 52 | 12:30 p.m. ABC
• UL Monroe at No. 21 Alabama (-37.5), 51 | 4:45 pm SEC Network
• East Tennessee State at No. 22 Tennessee (N/A) | 12:30 pm ESPN+/SEC
• Kennesaw State at No. 23 Indiana (-35.5), 50.5 | 12 pm FS1
• Kent State at No. 24 Texas Tech (-49), 59.5 | 7:30 pm TNT/MAX
• Cal Poly at No. 25 Utah (N/A) | 3 p.m. ESPN+

Next teams receiving votes in top 30: BYU, Auburn, Georgia Tech, USC, Louisville, TCU.

Other notable games Sat., Sept. 6

– Kansas at Missouri (-6), 51 – 12:30 pm
– Fresno State at Oregon State (-3), 48.5 – 12:30 pm
– Army at Kansas State (-16.5), 48.5 – 4 pm
– Houston (-12.5) at Rice, 40 – 4 pm
– Vanderbilt at Virginia Tech (-1), 47.5 – 4:30 pm
– Boston College at Michigan State (-3), 46 – 4:30 pm
– Ball State at Auburn (-43.5), 55.5 – 4:30 pm
– UCLA (-2.5) at UNLV, 55.5 – 5 pm
– Stanford at BYU (-18.5), 47.5 – 7:15 pm
– San Diego State at Washington State (-1.5), 45 – 7:15 pm

Week 2 Stability Score ratings fit Oregon State, UCLA and San Diego State with SDSU a best bet. Top 25 teams that fit stability score ratings as huge favorites include LSU, Indiana, Texas A&M and Auburn.

Notable Week 1 Stats, Rushing, Results

– Auburn rushed 52x for 307 yards and Baylor 64 rush yards in Tigers 38-24 road win.
– Florida State outrushes Alabama 230-74 in Seminoles (+13.5) big upset win over Crimson Tide, 31-17.
– Georgia (-38.5) wins 45-7 over Marshall with balanced attack 239 yards rushing and 249 passing.
– LSU (+3.5) wins at Clemson 17-10 with 108-31 rush edge.
– Georgia Tech rushed for 320 yards to 147 for Colorado in Yellow Jackets 27-20 road win and cover.
– Michigan win, no cover in 34-17 victory over New Mexico with Wolverines 200 club balanced offense, 201 rush, 251 pass.

Pointspread play of the week – Michigan State (-21.5) lead 23-0 with less than 4 minutes remaining in 4Q when Western Michigan got a 32-yard pick-6 interception return TD in Spartans 23-6 win. Rushing yards MSU 181, WMU 29.

College Football 2025 Week 2 Picks

See my college football football week 2 Picks and Opinions posted at Off Shore Gaming Association including Top 25 matchups and added Picks on Navy and San Diego State in non-Top 25 action and bonus totals pick.

More matchups, stats, updates and biggest early season games to follow along with college football 2025 Week 2 Picks and Opinions as college football draws more watch and wager action with added value betting at reduced juice sportsbooks like SuperBook Las Vegas and new Boomer’s Sportsbook at Ellis Island in Las Vegas (-105 NFL).

You can bet on it.