I’ve chipped-in some betting situations, systems, tips and trends plus additional information you can bet on along with the NFL Week 1 matchups and odds.
NFL Week 1 Betting Angles
Here are some betting angles supporting home underdogs in Week 1.
Betting Angle: Divisional home underdogs are 19-16-1 straight up (SU) and 25-11 against the spread (ATS) in Week 1 since 2009. I log weekly boxscore and betting data into spread sheets each week, and last season those home division ‘Dogs were 0-4 SU and 1-3 ATS. 
Leave it to the Browns to outgain the Bengals 327 (4.6 yards per play) to 141 (2.9) and have a 22-11 first down advantage, only to lose 17-16. All four divisional home underdogs lost close games by 4 points or less, and three of them outgained their division foes by 186, 98 and 63 yards in defeat. Of course the Browns were -2 in turnover margin. The previous year in 2024, home division ‘Dogs were 0-1 SU/1-0 ATS (Colts), and just 2-4 SU/ATS in 2023.
Home ‘Dogs overall in Week 1 last year were just 1-7 SU and 3-5 ATS. There are four home underdogs in Week 1 this season, but just one home divisional ‘Dog as the Giants (+3) host the Cowboys.
Also, BetUS reports that all Week 1 underdogs have hit greater than 54% ATS the last 13 seasons going 111-93-4 ATS (7-9, 7-9 and 10-6 ATS last 3 years) with divisional ‘Dogs 44-25-1 ATS (63.7%) home or away.
NFL Week 1 Games And Odds
Betting lines and NFL odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Point spread on favorites plus game totals, and division games in bold.
| Matchup | Spread | Total | Date |
|---|---|---|---|
| New England at Seattle | Seattle -3 | 44.5 | Wed., Sept. 9 |
| San Francisco vs. LA Rams | LA Rams -3.5 | 48 | Sept. 10 (Australia) |
| Cleveland at Jacksonville | Jacksonville -8 | 40.5 | Sun., Sept. 13 |
| Tampa Bay at Cincinnati | Cincinnati -4 | 50.5 | Sun., Sept. 13 |
| Baltimore at Indianapolis | Baltimore -3.5 | 48 | Sun., Sept. 13 |
| Atlanta at Pittsburgh | Pittsburgh -3 | 41.5 | Sun., Sept. 13 |
| Buffalo at Houston | Buffalo -1 | 44.5 | Sun., Sept. 13 |
| Chicago at Carolina | Chicago -2.5 | 47.5 | Sun., Sept. 13 |
| NY Jets at Tennessee | Tennessee -1 | 39.5 | Sun., Sept. 13 |
| New Orleans at Detroit | Detroit -7 | 50 | Sun., Sept. 13 |
| Arizona at LA Chargers | LA Chargers -10 | 47.5 | Sun., Sept. 13 |
| Miami at Las Vegas | Las Vegas -3.5 | 41 | Sun., Sept. 13 |
| Washington at Philadelphia | Philadelphia -5 | 45.5 | Sun., Sept. 13 |
| Green Bay at Minnesota | Minnesota -1 | 46 | Sun., Sept. 13 |
| Dallas at NY Giants | Dallas -3 | 48 | Sun., Sept. 13 |
| Denver at Kansas City | Kansas City -2.5 | 43.5 | Mon., Sept. 14 |
Five division games in Week 1 and just four road favorites overall. Check back next week for added stats and our weekly picks, props and parlays along with any additional tips, totals and trends.
NFL Week 1 ATS Tips and Trends
Here are some tips, trends and ATS situations and systems with data provided by the Vegas Stats & Information Network and Action Network media and research teams.
– NFL Week 1 double-digit favorites are 7-14 ATS since 2000. But there hasn’t been such favorite since 2019. This season kicks off with the Chargers (-10) laying double-digits at home against the Cardinals with select online sportsbooks still offering LAC -10.5.
– Week 1 underdogs of 6.5 points or more are 32-13-1 ATS (71.1%) since 2013. Teams that declined by 5 or more wins the previous season (KC, DET, WSH, MIN, AZ) are 26-13 ATS (66.7%) in the qualifying rebound spot Week 1.
– Jim Harbaugh is 6-0 SU/ATS in Week 1’s as an NFL head coach after the Chargers (+3) beat the Chiefs in last season 37-21. The Chargers are the only double-digit favorite in Week 1 this season.
– The Patriots and Chiefs have lost the last two Super Bowls in one-sided games (14+ points). In the Wild Card era (since 1990), there has been 13 teams lose by 14+ points in the Super Bowl the year prior. Those Super Bowl losers (not yet including Patriots) went 4-8 SU and 2-10 ATS in Week 1 of the next season. That includes eight consecutive losses ATS in Week 1, with the last team to cover being the 1997 Patriots beating the Chargers at home. The Patriots are a +3.5 point underdog at Seattle to kickoff Week 1 this season on Wed., Sept. 9.
– Packers head coach Matt LaFleur is 17-4 ATS within their first 3 games of the season since 2019, best of any team in the NFL. That includes 9-0 ATS at home in Lambeau Field. The Packers first home game this season is Week 3 on Thursday, Sept. 24 vs. the Falcons.
More updates, stats and ATS data as we research and chip-in more information you can bet on.
You can bet on it.
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