College Football Picks Week 6: Top 25 Odds, Matchups And Betting Update

The college football Week 6 schedule includes just one Top 25 matchup before the big Week 7 schedule that includes four Top 25 matchups on Sat., Oct. 12, headlined by Texas (-14.5) vs. Oklahoma in Dallas and Ohio State (-2.5) at Oregon. Last week’s huge watch and wager Top 5 matchup between Georgia and Alabama went the Crimson Tide’s way in a 41-34 win and wild finish. The victory moved Alabama to the top of the AP Top 25 rankings to kick off college football picks Week 6 in October.

Follow along each week as I provide my Picks, Opinions and Leans on Top 25 matchups and games, along with any bonus picks, in my college football coverage at Off Shore Gaming Association. Bonus picks went 6-0 ATS last year and this years Top 25 matchup picks are 2-3 and Week 5 added picks 1-2 with a best bet winner.

College Football Week 6 Odds

College football odds from leading online sportsbooks refresh periodically and are subject to change, including on props and live betting. All times Eastern and betting favorites (-) listed. 

Friday, Oct. 4 

No. 6 Oregon (-23.5) vs. Michigan State | 9 p.m. | FOX
No. 25 UNLV (-6.5) vs. Syracuse at | 9 p.m. | FS1

Saturday, Oct. 5 

No. 1 Alabama (-23) at Vanderbilt | 4:15 | SEC Network
No. 2 Texas | Bye
No. 3 Ohio State (-18.5) vs. Iowa | 3:30 p.m. | CBS – Bet Iowa
No. 4 Tennessee (-13.5) at Arkansas | 7:30 p.m. | ABC
No. 5 Georgia (-21.5) vs. Auburn | 3:30 p.m. | ABC/ESPN+
No. 7 Penn State (-27.5) vs. UCLA | 12 p.m. | FOX
No. 8 Miami (-10.5) at California | 10:30 p.m. | ESPN
No. 9 Missouri at No. 25 Texas A&M (-2) | 12 p.m. | ABC/ESPN+
No. 10 Michigan at Washington (-1.5) | 7:30 p.m. | NBC
No. 11 Southern California (-8) at Minnesota | 7:30 p.m. | BTN
No. 12 Ole Miss (-7.5) at South Carolina | 3:30 p.m. | ESPN
No. 13 LSU | Bye
No. 14 Notre Dame | Bye
No. 15 Clemson (-14.5) at Florida State | 7 p.m. | ESPN
No. 16 Iowa State (-12.5) vs. Baylor | 7:30 p.m. | FOX
No. 17 BYU | Bye
No. 18 Utah | Bye
No. 19 Oklahoma | Bye
No. 20 Kansas State | Bye
No. 21 Boise State (-26.5) vs. Utah State | 7 p.m. | FOX
No. 22 Louisville (-6.5) vs. SMU| 12 p.m. | ESPN
No. 23 Indiana (-13.5) at Northwestern | 3:30 p.m. | BTN
No. 24 Illinois | Bye

Other receiving votes: Arizona 106, Pittsburgh 42, Nebraska 30, Boston College 18, Iowa 17, James Madison 13, Oklahoma State 8, South Carolina 8, Rutgers 7, Kentucky 6, Navy 6, SMU 4, Army 2, Colorado 1

College Football Picks Week 6

Sat., Oct. 5

Arkansas (+13.5) vs. Tennessee
Washington  (-1.5) vs Michigan

Bonus Pick
Texas Tech (+6.5) at Arizona

See the game analysis on Picks plus additional Week 6 Opinions and analysis at OSGA. That includes the Top 15 matchup Missouri at Texas A&M plus Auburn at Georgia with notable Line moves.

Check back Saturday for any additional picks.

You can bet on it.

Update: 3-0 CFB Picks and 5-1 CFB Opinions on Sat., Oct. 5.
Opinion winners Texas A&M (-2), Auburn (+21.5) and Under (51.5), Arkansas (+13.5), Boise State (-26.5) and loser on Iowa (+18.5).