NFL 2025 Week 1 Picks And Preview

We kick off the NFL 2025 Week 1 picks and preview shooting for more touchdowns, birdies and green with our weekly NFL picks. I retired our NFL underdog picks (only) following a 57% ATS run over 7-seasons including a 70% ATS season (2021) before last year’s second half blowup with record ATS results for favorites. So I change the format this season with initial weekly picks, parlays and props posted at OSGA where you can see NFL 2025 Week 1 picks, insight, analysis and information you can bet on.

I also add some weekly totals including a Sunday Best Bet following a WTF moment and start in the Eagles 24-20 win over the Cowboys Thursday night to kickoff the NFL season (41 points 1st half and didn’t go over).

Check out some of my handicapping history, strategies and stories that included 8-straight winning NFL seasons as a top of the leaderboard professional handicapper.

NFL Week 1 Odds

Betting lines and NFL odds from top online sportsbooks including SuperBook Las Vegas below refresh periodically and are subject to change, including on props and live betting. NFL 2025 Week 1 point spread on favorites plus game totals, and division games in bold. Compare the Week 1 spreads and totals from openers released in May.

Sunday, Sept. 7

Pittsburgh (-3) at NY Jets, 38
Miami at Indianapolis (-1), 46.5
Carolina at Jacksonville (-3.5), 47
NY Giants at Washington (-6), 45.5
Cincinnati (-5) at Cleveland, 48
Las Vegas at New England (-2.5), 44
Arizona (-6.5) at New Orleans, 43
Tampa Bay (-1) at Atlanta, 47
Tennessee at Denver (-8.5), 42.5
San Francisco (-2) at Seattle, 43
Detroit at Green Bay (-2), 47
Houston at LA Rams (-3), 43
Baltimore (-1.5) at Buffalo, 50.5 – SNF
Minnesota (-1.5) at Chicago, 43.5 – Monday

Thursday and Friday saw Eagles (-8.5) win 24-20 but no cover vs. Cowboys, and Chargers (+3) outright win over the Chiefs in Brazil, 27-21 in opening two NFL Week 1 picks and and preview of games and division contests.

More NFL Week 1 tips, totals betting angles and information you can bet on. Check back for additional updates here ahead of Sunday, Sept. 7 games with select analysis from NFL 2025 Week 1 picks and post at OSGA.