College Football 2025 Week 9 Top 25 Preview And Picks

Some huge games and results in college football Week 8 action impacted the conference races, Top 25 and road to the College Football Playoff. Now three more Top 25 matchups are set for Saturday, Oct. 25 and all involve SEC teams. That includes Vanderbilt, who is up to No. 10 in the Top 25 after taking down LSU last Saturday.

• No. 8 Ole Miss vs. No. 13 Oklahoma
• No. 10 Vanderbilt vs. No. 15 Missouri
• No. 3 Texas A&M vs. No. 20 LSU

Just seven teams remain undefeated after UNLV from the Mountain West lost at Boise State.

Navy, Georgia Tech, BYU, Ohio State, Indiana, Texas A&M.

Navy leads the tight and most competitve American Athletic Conference (AAC) and the Middies are 4-0 in AAC play. South Florida and Tulane are 3-0 and four teams 6-1 overall. The Atlantic Coast Conference (ACC) has been turned upside down with huge preseason favorite Clemson now 3-4 after opening the season in the top 5 of the AP Top 25 Poll. Georgia Tech is unbeaten and 4-0 in ACC play with Virginia 3-0 and 6-1 overall and SMU also 3-0 and 5-2 overall in the ACC race after crushing Clemson 35-24. Louisville (5-1/2-1) is still in the race after taking down Miami 24-21 with the Hurricanes (5-1/1-1) having tough ACC road games remaining at SMU and Pittsburgh (5-2/3-1).

Brigham Young (BYU) leads the Big 12 at 4-0 with Cincinnati (6-1/4-0), Houston (6-1/3-1), Arizona State (5-2/3-1) and Texas Tech (6-1/3-1) in the conference chase after ASU picked up a huge win over Texas Tech 26-22 as a 7.5 point home ‘Dog in Tempe. Ohio State (7-0/4-0) and Indiana (7-0/4-0) are riding high and the Buckeyes are on a bye this week before tackling most disappointing Penn State (3-4/0-4) on Nov. 1 with the Nittany Lions a preseason No. 2 in the AP Top 25 Poll. Oregon (6-1/3-1) is still in the mix to return to the Big Ten Championship Game. Michigan, Iowa, USC, Minnesota and Northwestern are all 5-2 overall and 3-1 in Big Ten play with Minnesota at Iowa a key conference game this Saturday. And UCLA (3-4/3-1) is on a most improbable 3-game winning streak after firing their completely clueless head coach and responding under new coaches and coordinators.

College Football’s 2025 Top Defensive Teams

The SEC is loaded as expected with Texas A&M (7-0/4-0) on top this week and Alabama (6-1/4-0) the other unbeaten team in conference play after winning four straight games over Top 25 opponents including Tennessee last week with another WTF moment for underdog bettors. Georgia (6-1/4-1), Ole Miss (6-1/3-1), Oklahoma (6-1/2-1), Missouri (6-1/2-1), Vanderbilt (6-1/2-1) and Texas (5-2/2-1) are all pushing for a CFB Playoff spot and SEC title game appearance. Tennessee (5-2/2-2) and LSU (5-2/2-2) will factor into the SEC leaders results with games remaining vs. A&M, and on the road at Alabama and Oklahoma.

Winning profiles and Stats – College Football Balanced Offenses

Top 25 Games and Week 9 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals. All times ET. Top 25 matchups in bold.

Saturday, Oct. 25

No. 1 Ohio State | Bye
No. 2 Indiana (-25) vs UCLA, 54.5 | 12 pm | FOX
No. 3 Texas A&M (-2.5) at No. 20 LSU, 47.5 | 7:30 pm | ABC
No. 4 Alabama (-12) at South Carolina, 47.5 | 3:30 pm | ABC
No. 5 Georgia | Bye
No. 6 Oregon (-33.5) vs Wisconsin, 44.5 | 7 pm | FS1
No. 7 Georgia Tech (-17.5) vs Syracuse, 53.5 | 12 pm | ESPN
No. 8 Ole Miss at No. 13 Oklahoma (-5), 54.5 | 12 pm | ABC
No. 9 Miami (-30) vs Stanford, 45 | 7 pm | ESPN
No. 10 Vanderbilt (-2.5) vs No. 15 Missouri, 48.5 | 3:30 pm | ESPN
No. 11 BYU at Iowa State (-2.5), 49 | 3:30 pm | FOX
No. 14 Texas Tech (-38.5) vs Oklahoma State, 56.5 | 4 pm | ESPNU
No. 16 Virginia (-10.5) at North Carolina, 51.5 | 12 pm | ACCN
No. 17 Tennessee (-9.5) at Kentucky, 55 | 7:45 pm | SECN
No. 18 South Florida (-5) at Memphis, 63 | 12 pm | ESPN2
No. 19 Louisville (-25.5) vs Boston College, 55 | 7:30 pm | ACCN
No. 21 Cincinnati (-4.5) vs Baylor, 67.5 | 4 pm | ESPN2
No. 22 Texas (-7) at Mississippi State, 44.5 | 7:15 pm | SECN
No. 23 Illinois at Washington (-4.5), 54.5| 3:30 pm | Big Ten Network
No. 24 Arizona State vs Houston | 3:30 pm | FOX
No. 25 Michigan (-14.5) at Michigan State, 48 | 7:30 pm | NBC

Others receiving votes: USC, Utah, Tulane, Houston, Navy, San Diego State, James Madison, Boise State, TCU, Minnesota

Michigan, Arizona State and Illinois all reentered the AP Top 25 after their Week 8 victories, while Louisville debuted in the Top 25 at No. 19 following its upset of previous No. 3 Miami. Four teams between No. 20 and No. 25 lost their Week 8 games  to fall out of the Top 25 including USC to Notre Dame in South Bend, which saw a big line move from ND -8′ to -10.5 in the Irish 34-24 win. Memphis was upset by UAB on the road, Utah narrowly lost to undefeated BYU, and Nebraska was routed by Minnesota on Friday night.

Other notable games on Sat., Oct. 25

– Minnesota at Iowa (-9), 39 – CBS
– Auburn at Arkansas (pk), 57 – SECN
– SMU (-3.5) at Wake Forest, 54.5 – CW
– NC State at Pittsburgh (-6.5), 56.5 – ACCN
– Kansas State at Kansas (-2.5), 57 – TNT
– Western Michigan at Miami, Ohio (-1.5), 41 – ESPN+
– San Diego State )(-3) at Fresno State, 48 – FS1
– Colorado State at Wyoming (-5.5), 46 – CBSSN
– FAU at Navy (-14.5), 62.5 – CBSSN
– Colorado at Utah (-13.5), 49 – ESPN

NCAA Football Week 9 Top 25 Picks

See OSGA and college football 2025 Week 9 game analysis for more details on picks.

Ole Miss at Oklahoma – Pick Oklahoma
Missouri at Vanderbilt – Opinion Vanderbilt
Texas A&M at LSU – Lean LSU

More select game analysis, picks and opinions as available by Saturday. Additional watch and wager college football action with added value betting.