College Football 2025 Week 13 Top 25 Preview And Picks

The college football 2025 Week 13 games includes two Top 25 matchups ahead of next week’s biggest rivalry games, which I cover for BetOnline. Fairways Forecast chips in more picks and opinions on the most watched and wagered biggest games in November with College Football Playoff rankings.

The big Week 12 included a pair of top 10 SEC matchups, and Oklahoma knocked off Alabama 23-21 in Tuscaloosa to keep their College Football Playoff hopes alive. The top 5 SEC teams in the playoff chase includes Oklahoma in another Top 25 matchup against Missouri this week. Ole Miss has a bye, while Texas A&M, Georgia and Alabama have soft non-conference FCS opponents with all three favored by at least 43 points.

Check out more Top 25 coverage, analysis and picks in my college football 2025 Week 13 report at Off Shore Gaming Association.

Top 25 Games and Week 13 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals and updated as of Thursday, Nov. 20. All times ET. Top 25 matchups in bold.

Sat., Nov. 22

– No. 1 Ohio State (-31.5) vs Rutgers, 54.5 | 12 pm | FOX
– No. 2 Indiana | Bye
– No. 3 Texas A&M (-54.5) vs Samford, 59.5 | 12 pm | SECN
– No. 4 Georgia (-43.5) vs Charlotte, 53.5 | 12:45 pm | SECN
– No. 5 Texas Tech | Bye
– No. 6 Mississippi | Bye
– No. 7 Oregon (-10) vs No. 15 USC, 59.5 | 3:30 pm | CBS
– No. 8 Oklahoma (-7.5) vs No. 22 Missouri, 42 | 12 pm | ABC
– No. 9 Notre Dame (-35) vs Syracuse, 50.5 | 3:30 pm | NBC
– No. 10 Alabama (-50.5) vs Eastern Illionis, 57.5 | 2 pm | SECN
– No. 11 BYU (-2.5) at Cincinnati, 55 | 8 pm | FOX
– No. 12 Utah (-17.5) vs Kansas State, | 4 pm | ESPN2
– No. 13 Miami (-17.5) at Virginia Tech, 49 | 12 pm | ESPN
– No. 14 Vanderbilt (-9.5) vs Kentucky, 53 | 3:30 pm | ESPN
– No. 16 Georgia Tech (-3 vs Pittsburgh, 62 | 7 pm |
– No. 17 Texas (-9) vs Arkansas, 57.5 | 3:30 pm | ABC
– No. 18 Michigan (-14) at Maryland, 46.5 | 7 pm | Big Ten
– No. 19 Virginia | Bye
– No. 20 Tennessee (-4) at Florida, 57 | 7:30 pm | ABC
– No. 21 Illinois (-7.5) at Wisconsin, 42 | 7:30 pm | Big Ten
– No. 23 Houston (pk) vs TCU, 55 | 7 pm | FOX
– No. 24 Tulane (-9) at Temple, 55.5 | 3:45 pm | ESPNU
– No. 25 Arizona State (-7) at Colorado, 48.5 | 8 pm | ESPN2

Other notable games Week 13

Teams in bold have 5 wins and playing to become bowl eligible

– Louisville at SMU (-2.5), 52
– Kansas at Iowa State (-3.5), 55.5
– Minnesota at Northwestern (-3.5), 40.5
– Baylor at Arizona (-7), 62
– Duke (-7) at North Carolina, 51.5
– East Carolina (-2.5) at UTSA, 62
– Nebraska at Penn State (-8), 44.5
– Cal (-3) at Stanford, 47
– Washington (-10.5) at UCLA, 51.5
– Utah State at Fresno State (-2.5), 51

NCAA Football Week 13 Top 25 Picks

See OSGA for game analysis.

• USC at Oregon – Opinion: USC
• Missouri at Oklahoma – Opinion: Oklahoma
• Rutgers at Ohio State – Opinion: Rutgers

Non Top 25 – Saturday

• Baylor (+7) at Arizona
• Nebraska (+8.5) at Penn State – former Top 25 teams
• Colorado State at Boise State (-16.5)

The biggest game of the week is in the Big Ten between No. 15 USC and No. 7 Oregon in Eugene.

More college football updates as available ahead of next week’s big rivalry games with conference and College Football Playoff implications between Ohio State-Michigan, Texas A&M-Texas and Alabama-Auburn.

You can bet on it.