College Football 2025 Week 10 Top 25 Preview And Picks
The first Saturday of November kicks off a big month of college football 2025 Week 10 action. Top teams and leading contenders push towards conference titles, College Football Playoff spots and some of the biggest rivalry games. Tuesday, Nov. 4 is the first release of College Football Playoff rankings. The initial release won’t include Penn State or Clemson, preseason top 5 teams and favorites to win the Big Ten and ACC and now both teams with losing records at 3-4 into November.
I provide initial NCAA football Top 25 coverage, updates and picks at Off Shore Gaming Association.
Three Top 25 matchups for college football 2025 Week 10, and for the second straight week it includes Vanderbilt. The Commodores are just a 1-point underdog at Texas after opening Longhorns -2.5, but check all current lines as they can change during the week ahead kickoff.
One noteable matchup that is not between Top 25 teams and has a huge line adjustment from preseason is Penn State at Ohio State. The Buckeyes are -20.5 point favorite, and the preseason line was Ohio State -4.5. It that isn’t bad enough for the Nittany Lions, while also playing without their starting quarterback Drew Allar (broken ankle Oct. 11), Penn State has lost eight straight to Ohio State since 2017.
Top 25 Games and Week 10 Odds
Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals. All times ET. Top 25 matchups in bold.
Saturday, Nov. 1
No. 1 Ohio State (-20.5) vs Penn State, 43 | 12 pm | FOX
No. 2 Indiana (-21.5) at Maryland, 51.5 | 3:30 pm | CBS
No. 3 Texas A&M | Bye
No. 4 Alabama | Bye
No. 5 Georgia (-7.5) vs. Florida, 50 (Jacksonville | 3:30 | ABC
No. 6 Oregon | Bye
No. 7 Ole Miss (-12.5) vs South Carolina, 54.5 | 7 pm | ESPN
No. 8 Georgia Tech (-5.5) at NC State, 57.5 | 7:30 pm | ESPN2
No. 9 Vanderbilt at No. 20 Texas (-1), 45 | 12 pm | ABC
No. 10 Miami (-11.5) at SMU, 50.5 | 12 pm | ESPN
No. 10 BYU | Bye
No. 12 Notre Dame (-28.5) at Boston College, 58 | 3:30 pm| ESPN
No. 13 Texas Tech (-7.5) at Kansas State, 52.5 | 3:30 pm | FOX
No. 14 Tennessee (-3) vs. No. 18 Oklahoma, 57 | 7:30 pm | ABC
No. 15 Virginia (-3.5) at Cal, 54 | 3:45 pm | ESPN2
No. 16 Louisville (-10.5) at Virginia Tech, 54 | 3 pm | CW
No. 17 Cincinnati at No. 24 Utah (-7.5), 56.5 | 10:15 pm | ESPN
No. 19 Missouri | Bye
No. 21 Michigan (-21) vs Purdue, 51 | 7 pm | Big Ten
No. 22 Houston (-14) vs West Virginia, 49 | 12 pm | FS1
No. 23 USC (-7) at Nebraska, 59| 7:30 pm | NBC
No. 25 Memphis (-14) at Rice, 49.5 | 7 pm (Friday) | ESPN2
Others receiving votes: Navy, Tulane, Washington, Iowa, South Florida, San Diego State, LSU, James Madison, North Texas, Illinois, Pittsburgh
Other notable games on Sat., Nov. 1
– Arizona State at Iowa State (-5.5), 50.5
– Mississippi State at Arkansas (-4.5), 57.5
– Navy at North Texas (-6), 65.5
NCAA Football Week 9 Top 25 Picks
See OSGA and college football 2025 Week 9 game analysis for more details on picks.
Vanderbilt at Texas – Opinion: Texas
Oklahoma at Tennessee – Pick: Tennessee
Cincinnati at Utah – Opinion: Utah
Other games and Opinions:
Miami at SMU (+10.5 to 11.5)
Duke at Clemson (-3 / 3.5)
Mississippi State at Arkansas (-4.5)
Kentucky at Auburn (-10 / 10.5)
USC at Nebraska – Over 59
More select game analysis and picks obove added late Friday at OSGA. Additional watch and wager college football action with added value betting.
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