College Football 2026 Week 6 Top 25 Preview And Picks

Top 25 Preview and Picks for Week 6 of the College Football season

The college football 2026 Week 6 schedule includes three Top 25 matchups, plus the annual big game betting battle between unranked Oklahoma and No. 1 Texas in the Red River Rivalry in Dallas. Our Top 25 preview for college football 2026 Week 5 also includes the most anticipated SEC game with No. 2 Georgia at No. 6 Alabama, which is on a weather watch with hurricane Isaias heading towards Tuscaloosa. The Bulldogs (5-0) and Crimson Tide (5-0) are tied at 3-0 on top of the SEC. No. 21 UCLA at No. 13 Oregon is a Big Ten battle with both teams rested and ready off a bye week.

Our weekly Top 25 picks and additional games of interest and opinions are part of the Week 6 Top 25 betting report driving more watch and wager action at leading online sportsbooks. We’ve been adding more picks beyond just the Top 25 teams, and following an 8-2 ATS result on our Week 4 college football picks and opinions, initially posted at Off Shore Gaming Association. Another huge card in Week 5 produced a 10-4 ATS week, and 18-6 ATS the past week as part of our winning season.

The top 5 teams in the AP Top 25 Poll remain the same with Texas, Georgia, Notre Dame, Miami and Ohio State. Alabama and Indiana swap spots at No. 6 and No. 7, but Florida drops out of the top 10 following their loss at Missouri. No. 8-10 are BYU, Ole Miss and LSU.

From the betting lines and adjustments at leading online sportsbooks to key matchups, insight and odds updates, there is plenty of action in Week 6.

Taking advantage of the sportsbooks bonus offers and shopping for the best lines will increase your odds of winning, including betting with reduced juice sportsbooks.

Top 25 Games and Week 6 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live/in-game betting. Point spread on favorites plus game totals. All times ET.

Check back by Friday each week and my updates @FairwayJay on X as Fairways Forecast adds additional Picks and Opinions plus any upgrades with select game analysis, stats and information you can bet on.

Fri, Oct. 9

– No. 20 Iowa at Washington (-3), 41 | 9 pm | ESPN
– Iowa State at No. 8 BYU (-11), 47 | 10:15 pm | ESPN

Sat, Oct. 10

– No. 1 Texas (-8) vs. Oklahoma, 39.5 | 3:30 pm | ABC
– No. 2 Georgia at No. 6 Alabama (-2), 55.5 | 7:30 pm | ABC
– Stanford at No. 3 Notre Dame (-37.5), 54 | 3:30 pm | NBC
– No. 4 Miami | Bye, next week vs. Florida State
– Maryland at No. 5 Ohio State (-33), 56.5 | 4:15 pm | BIGN
– No. 7 Indiana (-7.5) at Nebraska, 52 | 12 pm | FOX
– No. 9 Ole Miss (-9.5) at Vanderbilt, 59 | 3:30 pm | ESPN
– No. 10 LSU (-9.5) at Kentucky, 54 | 7 pm | ESPN
– No. 11 Texas Tech | Bye, next week vs. Arizona State
– Kansas at No. 12 Utah (-15.5), 52 | 10:15 pm | ESPN
– No. 21 UCLA at No. 13 Oregon (-12), 59 | 3:30 pm | CBS
– Texas A&M at No. 14 Missouri (-3.5), 48.5 | 12 pm |
– No. 15 Tennessee (-13.5) at Arkansas, 50.5  | 4:15 pm |
– South Carolina at No. 16 Florida (-13.5), 62  | 12:45 pm |
– No. 17 Mississippi State | Bye, next week at LSU
– Central Florida at No. 18 Oklahoma State (-9), 54 | 12 pm | ESPN2
– No. 19 USC at Penn State (-1.5), 55 | 7 pm |
– No. 22 Houston at Kansas State (-2.5), 56.5 | 3:30 pm |
– No. 23 Boise State (-6) at Fresno State, 48.5 | 10:30 pm | CW
– No. 24 SMU | Bye, next week vs. Virginia
– North Carolina at No. 25 Pittsburgh (-4), 47 | 12 pm | ESPN

Others receiving votes: Kentucky 160, Wake Forest 142, Wisconsin 88, Duke 83, Northwestern, Nebraska, Minnesota, Arizona, James Madison, North Dakota State.

Other Week 6 games of interest

– Florida State at Louisville (-3.5), 59 – Friday
– Wyoming at San Jose State (-6.5), 43 – Friday
– Washington State at Utah State (-6), 43 – Friday
– Tulane at Army (-3), 48
– Arizona (-3.5) at West Virginia, 61.5
– Wake Forest (-4) at NC State, 60
– Ball State at Northwestern (-36), 53
– Illinois (-2.5) at Michigan State
– Cental Michigan at Ohio (-3), 46.5
– Eastern Michigan (-7) at Akron, 52
– Kent State at Western Michigan (-13.5), 43.5
– Duke (-7) at Georgia Tech, 49.5
– Virginia Tech (-9) at Cal, 52.5
– Tulsa at Navy (-2.5), 48.5
– UCONN at Temple (-3.5), 54.5
– San Diego State at Oregon State (-14), 55
– UAB at Memphis (-14), 57.5
– North Dakota State (-3) at UNLV, 48
– Syracuse at Virginia (-9), 50
– James Madison (-7.5) at Georgia Southern, 54.5
– Air Force (-7) at Northern Illinois, 47
– Minnesota (-2) at Purdue, 51
– Hawaii at Arizona State (-20.5), 51

Week 6 College Football Picks

Top 25

– USC (+1.5)

NCAA Football Opinions

– Nebraska (+7.5)

Non-Top 25 – Picks and Opinions (P & O)

Texas vs. Oklahoma – Stats and analysis by Friday

Georgia at Alabama – Stats and more analysis by Friday. Weather update: A potential hurricane (Isaias) could force changes to Saturday night’s big SEC game in Tuscaloosa. The weather threat could force a time change from the scheduled 7:30 p.m. ET kickoff. Top online sportsbooks have adjusted the total as the betting market has reacted. The game total has fallen from 57 to 52.5 points with the Crimson Tide a 1.5 to 2-point home favorite.

UCLA at Oregon – Both the Bruins and Ducks enter rested and ready off a bye, and looking up at six teams in the Big Ten standings. Oregon (3-1/1-0 Big Ten) suffered the surprising loss at now Top 25 Oklahoma State as a 24-point favorite. UCLA (4-0/2-0) continues to impress in coach Bob Chesney‘s first season in Westwood. The Bruins defense is allowing less than 19 points per game, and UCLA’s offense ranks top 10 averaging 486 yards per game (Oregon 427). UCLA has beaten all four opponents by at least 14 points including their recent blowout win at Maryland, 54-3.

Indiana at Nebraska – A battle of unbeatens in college football 2026 Week 6 with both teams 5-0 and tied on top of the Big Ten at 2-0 with UCLA, Minnesota, Ohio State and Wisconsin. This is Indiana’s first road game, and it will be an electric atmosphere in Lincoln with 85,000+ fans supporting Big Red and FOX Sports Big Noon kickoff adding to the big game coverage. Sunny skies and mid-80’s temps with big watch and wager action with the nation’s best sellout streak (Nebraska, 411 consecutive games) against the team with the longest winning streak in college football in defending national champion Indiana.

Nebraska has won all five games this season by at least 18 points including 31-13 at Michigan State and last week’s dominant second half to maul Maryland, 48-23. The Hoosiers run the ball 59% of the time and 37 carries per game for 242 yards per game. Nebraska 53% rushes, 38 rushing attempts per game for 220 yards per game, also top 10 in the country.

Nebraska is averaging 46 points per game (top 3 behind Georgia and Alabama) at 6.5 yards per play vs. FBS opponents and Indiana 41.5 ppg with a Power 4 conference-best 7.6 yards per play. The Cornhuskers defense allows 16 ppg and Indiana 13.5 ppg, both top 15 in the country. Defensive yards allowed are nearly even at 281/283 and 4.4/4.5 yards per play. Both teams defenses are top 25 in opponents yards per point with Indiana a bit better while playing a softer schedule thus far. Indian’s best win was 29-23 over Northwestern as a 20.5 point favorite in a game they led just 15-13 early in the 4th quarter. Indiana did dominated the line of scrimmage and held the Wildcats to 33 rushing yards and 325 total yards.

Pro Football Focus (PFF) grades Nebraska as having the No. 17 offense and No. 61 defense in the country. Indiana’s schedule ranks 105th in the PFF NCAA Power Rankings. The Hoosier’s rank No. 2 in the FBS in both offensive EPA per play (0.37) and points per drive (3.67). Indiana has also been excellent defensively, tying for 14th in EPA allowed per play (-0.17) and ranking fourth in points allowed per drive (0.87).

Check back Friday for more picks and opinions and additional, stats, analysis and information you can bet on.

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