College Football 2025 Week 12 Top 25 Preview And Picks

Following Week 11 and 2-0 on picks plus 2-1 opinions, Fairways Forecast chips in more picks and opinions on the most watched and wagered biggest games in November with College Football Playoff rankings. Four college football 2025 Top 25 matchups in Week 12 including a pair of top 10 SEC matchups. Check out my coverage and more picks and analysis at Off Shore Gaming Association.

The coaching carousel and changes continue, and I provide an update for BetOnline including at Penn State, who we cashed-in for Week 11 picks as big home ‘Dog and a last second loss to No. 2 Indiana.

Top 25 Games and Week 12 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals and updated as of Wednesday, Nov. 12. All times ET. College Football 2025 Week 12 Top 25 matchups in bold.

Sat., Nov. 15

– No. 1 Ohio State (-31.5) vs UCLA, 48.5 | 7:30 pm | NBC
– No. 2 Indiana (-29.5) vs Wisconsin, 44 | 12 pm | Big Ten Network
– No. 3 Texas A&M (-19) vs South Carolina, 48 | 12 pm | ESPN
– No. 4 Alabama (-6) vs. No. 11 Oklahoma, 46 | 3:30 pm | ABC
– No. 5 Georgia (-6) vs No. 10 Texas, 49 | 7:30 pm | ABC
– No. 6 Texas Tech (-23.5) vs UCF, 48 | 3:30 pm | FOX
– No. 7 Ole Miss (-16.5) vs Florida, 54 | 7 pm | ESPN
– No. 8 Oregon (-25) vs Minnesota, 44 | 9 pm | FOX (Friday)
– No. 9 Notre Dame (-13) at No. 22 Pittsburgh, 56 | 12 pm ABC
– No. 12 BYU (-4.5) vs TCU, 52.5 | 10:15 pm | ESPN
– No. 13 Utah (-8) at Baylor, 60.5 | 7 pm | ESPN
– No. 14 Virginia (-7) vs. Wake Forest, 48 | 7 pm | ESPN
– No. 15 Miami (-14.5) vs NC State, 55.5 | ESPN
– No. 16 Georgia Tech (-16.5) at Boston College, 59 | 3:30 pm | ACCN
– No. 17 USC (-6.5) vs No. 21 Iowa, 49.5 | 3:30 pm | Big Ten Network
– No. 18 Michigan (-11.5) at Northwestern, 41 | 12 pm | FOX
– No. 19 Virginia (-14.5) at Duke, 55.5 | 3:30 pm | ESPN2
– No. 20 Louisville (-3) vs Clemson, 50 | 7:30 pm | ESPN
– No. 23 Tennessee (-39.5) vs New Mexico State, 62 | 4:15 pm | SECN
– No. 24 South Florida (-10.5) at Navy, 64.5 | 12 pm | ESPN2
– No. 25 Cincinnati (-6.5) vs Arizona, 56 | 12 pm | FS1

Other notable games Week 12

Teams in bold have 5 wins and playing to become bowl eligible

– Arkansas at LSU (-5.5), 56
– Penn State (-7) at Michigan State, 50 (both teams 0-6 in Big Ten!)
– Appalachian State at James Madison (-21), 53.5
– Memphis at East Carolina (-3), 59
– Florida Atlantic at Tulane (-17.5), 63
– North Carolina at Wake Forest (-6), 38.5
– Utah (-8) at Baylor, 60.5
– Utah State at UNLV (-6), 71
– Mississippi State at Missouri (-7), 51.5
– Boise State at San Diego State (-3), 41
– Buffalo at Central Michigan (-2), 44 (Wednesday)
– Toledo (-4.5) at Miami O, 45.5 (Wednesday)
– Baylor, NC State and Northwestern have 5 wins in their matchups vs Top 25 opponents

NCAA Football Week 12 Top 25 Picks

See OSGA for game analysis.

Notre Dame at Pittsburgh – Pick: Pittsburgh

Oklahoma at Alabama – Opinion: Oklahoma

Iowa at USC – Lean: Iowa

Texas at Georgia – Opinion: Texas

– TCU at No. 12 BYU – Opinion: TCU
– No. 13 Utah at Baylor – Opinion: Baylor

Appalachian State at James Madison (-21) – Pick: James Madison

The ACC remains wide open with four teams 5-1 in conference play – Georgia Tech, Virginia, Pittsburgh and Virginia. Duke is also 4-1 and playing for bowl eligibility at 5-4 overall. Georgia Tech (8-1) is the only one loss team overall, and Pitt gets a shot a Notre Dame this week and the Panthers are a running, defensive ‘Dog that will payoff.

You can bet on it.