NFL 2025 Week 10 Picks, Props, Parlays And Preview

Our NFL 2025 Week 10 picks, parlays and props continue as we shoot for more winners including player props which are 13-5 since Week 3. Full details, analysis and Week 10 picks with information you  can bet on is intially posted at Off Shore Gaming Association, where we posted NFL underdog picks only and hit 57% ATS from 2017-2023 before changing formats to more coverage including tips, totals, teasers and trends, which I posted earlier for Week 10.

NFL Week 10 Odds

Betting lines and NFL odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Point spread on favorites and division games in bold.

– Las Vegas at Denver (-9), 43 – Thursday (Broncos win 10-7)
– Atlanta vs Indianapolis (-6.5), 48 – Berlin, Germany
– Cleveland (-2.5) at New York Jets, 37.5
– New Orleans at Carolina (-5.5), 39.5
– Buffalo (-9.5) at Miami, 50
– Jacksonville (-1.5) at Houston, 37.5
– Baltimore (-4.5) at Minnesota, 49
– New England at Tampa Bay (-2.5), 48
– New York Giants at Chicago (-4.5), 46.5
– Arizona at Seattle (-6.5), 45
– Detroit (-8) at Washington, 49
– Los Angeles Rams (-5) at San Francisco, 49.5
– Pittsburgh at Los Angeles Chargers (-2.5), 44.5 SNF
– Philadelphia at Green Bay (-1.5), 46 MNF

NFL Week 10 Picks

Picks: Panthers
Opinions: Bears

Not as much to like or interest in the NFL 2025 Week 10 picks, and I’ll add more to the parlays below over the weekend with more research and injury review, noting more injuries on the Falcons for the early Sunday kickoff versus the Colts in Germany.

3-team parlay: Panthers, Bears, Chargers
2-team ‘Dog parlay: Texans, Patriots

Be sure to review the NFL injury reports along with NFL weather as rain is forcast in a number of cities plus snow and some stronger gusting winds in Chicago and Monday night in Green Bay.

Saints-Panthers

Seems a bit difficult to support the Panthers (5-4) laying more points with a mostly clueless quarterback in Bryce Young, whose passing stats and metrics are among the worst in the league. But Carolina’s rushing attack is top-5 and up to 140 yards per game with RB Rico Dowdle running wild and leading the NFC in rushing (735 yards) while averaging 5.6 yards per rush. The Panthers also run the ball an average of 30 times per game (a key stat & winning ATS results) including 32.1 over their last three contests. Consider too that the Saints (1-8 SU / 2-7 ATS) run the ball just 23.6 times per game including a league-low 15.3 over their last three contests and have a rookie quarterback making his second start. The Saints run defense ranks in the bottom quartile of the league allowing 129 ypg and allow a league-high 32.2 rushing attempts per game. The Panthers have allowed just 73 rushing yards per game in their five wins, and the Saints awful ground game combined with rookie quarterback Shough making his second start and now without traded WR Rashid Shaheed makes it more difficult to move the ball. The Saints have the NFC’s worst scoring offense (15.3 ppg) and have failed to score 20 or more points in 6 of their last 7 games while averaging just 9 points per game over their last three contests. This is the most lopsided rushing projection on the Week 10 card, although the last time it lined up as such, at least on paper, we took it in the A– when the Falcons (-7) lost at home 34-10 to the lowly Dolphins. Still, Panthers should be on the prowl and know too that NFL teams that win the game straight up are 87-7 ATS this season in competitively-lined games (6 or less).

Giants-Bears – The Bears and their league-best +13 turnover margin also project to have a big rushing game edge over the Giants at home in Chicago.

See more picks, parlays and props at OSGA with coverage of the big NFC West showdown Los Angeles Rams and San Francisco 49ers.

NFL Player Props 

– Rams QB Matthew Stafford – Over 263.5 passing yards
– Lions WR Amon-Ra St. Brown – Over 77.5 receiving yards

Looking ahead to NFL Week 11, nine division games make it a most meaningful week with the Broncos-Chiefs game in Denver and Seahawks-Rams showdown in Los Angeles headlining the key Week 11 contests which I outline for BetOnline.

You can bet on it.