College Football 2025 Week 11 Top 25 Preview And Picks

The 2025 college football season continues into Week 11 with three Top 25 matchups on Nov. 8 from the recently released College Football Playoff Selection Committem Rankings.

Check out my college football 2025 Week 11 coverage at Off Shore Gaming Association for more detailed insight and analysis including College Football Playoff rankings and the biggest games games to watch and wager on in the closing weeks of the college football season.

Four undefeated teams reamin into Week 11 – Ohio State, Indiana, Texas A&M and Brigham Young (BYU).

Top 25 Games and Week 11 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals and updated as of Friday, Nov. 8. All times ET. Top 25 matchups in bold.

Sat., Nov. 8

– No. 1 Ohio State (-29.5) at Purdue, 48 | 1 pm | Big Ten Network
– No. 2 Indiana (-14.5) at Penn State, 50 | 12 pm | FOX
– No. 3 Texas A&M (-7) at No. 22 Missouri, 48.5 | 3:30 pm | ABC
– No. 4 Alabama (-10.5) vs. LSU, 49.5 | 7:30 pm | ABC
– No. 5 Georgia (-9.5) at Mississippi State, 56 | 12 pm | ESPN – No. 6 Ole Miss vs The Citadel | 1 pm | SECN+
– No. 7 BYU at No. 8 Texas Tech (-11), 51.5 | 12 pm | ABC –
– No. 9 Oregon (-6.5) at No. 20 Iowa, 41.5 | 3:30 pm | CBS
– No. 10 Notre Dame (-27.5) vs. Navy, 55 | 12 pm NBC/Peacock
– No. 11 Texas | Bye
– No. 12 Oklahoma | Bye
– No. 13 Utah | Bye
– No. 14 Virginia (-7) vs. Wake Forest, 48 | 7 pm | ESPN
– No. 15 Louisville (-20.5) vs. Cal, 50.5 | ESPN2
– No. 16 Vanderbilt (-6.5) vs. Auburn, 45 | 7 pm | SECN
– No. 17 Georgia Tech | Bye
– No. 18 Miami (-28.5) vs. Syracuse, 46 | 3:30 pm | ESPN
– No. 21 Michigan | Bye
– No. 23 Washington (-11) at Wisconsin, 44 | 7:30 pm | Big Ten Network
– No. 24 Pittsburgh | Bye
– No. 25 Tennessee | Bye

Southern Cal (-14) kicked off the Week 11 action for ranked teams at home Friday night against Northwestern – update, USC wins 38-17.

Other notable games on Sat., Nov. 8  

– Florida State at Clemson (-1), 56
– Duke (-8.5) at Connecticut, 63.5
– Iowa State at TCU (-7.5), 56.5
– Tulane at Memphis (-4.5), 55
– Wake Forest at Virginia (-6.5), 48
– San Diego State (-7) at Hawaii, 48.5

NCAA Football Week 11 Top 25 Picks

See OSGA for picks and opinions plus analysis. One Big Ten matchup below.

Indiana at Penn State – Pick: Penn State

I had this as a top pick early week and Playbook Sports notes that undefeated college football road favorites from Game 10 forward are 24-48-1 ATS since 1990 including a bankroll-busting 6-24 ATS as a double-digit favorite when facing a team that allows 23 or fewer points per game. The pressure continues to mount on these teams, and Indiana (9-0 / 6-0) is sitting pretty on top of the Big Ten with Ohio State and sporting a strong, balanced offense and top defense. But the Hoosiers have never been in such rarified air, and just achieved their highest-ever College Football Playoff ranking. No teams power rating has risen more than Indiana this season, and Penn State (3-5 / 0-5) has seen their power rating fall the furthest. The Nittany Lions lost their starting quarterback and fired head coach Franklin a few weeks ago, and Penn State has failed against the spread (1-7) by more than 80 points while Indiana has buried their opponents by more than 130 points to the spread. Penn State would have been more than a 10 point favorite in this matchup at the start of the season making this one of the biggest point spread adjustments you will see.

BYU at Texas Tech – Opinion: Texas Tech

Texas A&M at Missouri– Opinion: Missouri

Oregon at Iowa – Opinion: Iowa

Non-Top 25

San Diego State at Hawaii – Pick: Hawaii

More College Football Playoff rankings, odds and potential CFB matchups and projected odds in my coverage at OSGA.