College Football 2025 Week 8 Top 25 Preview And Picks

Five Top 25 matchups in college football 2025 Week 8 includes three in the SEC, a Holy War in the Big 12 plus No. 20 USC at No. 8 Notre Dame after the Trojans delivered our top pick winner in Week 7 Top 25 action with a 31-13 mauling of Michigan.

Now we take some strong teams as underdogs in Week 8 with solid profiles and stats including elite and efficient balanced offenses of USC, Tennessee and Ole Miss.

Along with USC at Notre Dame, the other most watched and wagered games on Saturday, Oct. 18 include:

– No. 10 LSU at No. 17 Vanderbilt
– No. 5 Ole Miss at No. 9 Georgia
– No. 11 Tennessee at No. 6 Alabama
– No. 23 Utah at No. 15 BYU

Top 25 Games and Week 8 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites, plus game totals. All times ET. Top 25 matchups in bold with odds as of Tuesday with the biggest Week 8 line moves noted here.

Saturday, Oct. 18

(Two Top 25 teams playing Friday, No. 3 Miami and No. 25 Nebraska)

No. 1 Ohio State (-26) at Wisconsin, 40.5 | 3:30 pm | CBS
No. 2 Miami (-13.5) vs. Louisville, 52 | 7 pm | ESPN
No. 3 Indiana (-27) vs Michigan State, 52.5 | 3:30 pm | Peacock
No. 4 Texas A&M (-7.5) at Arkansas, 61.5 | 3:30 pm | ESPN
No. 5 Ole Miss at No. 9 Georgia (-7.5), 54.5 | 3:30 pm | ABC
No. 6 Alabama (-8.5) vs No. 11 Tennessee, 58.5 | 7:30 pm | ABC
No. 7 Texas Tech (-9.5) at Arizona State, 51.5 | 4 pm | FOX
No. 8 Oregon (-17) at Rutgers, 60.5 | 6:30 pm | FOX
No. 10 LSU at No. 17 Vanderbilt (-2.5), 48.5 | 12 pm | ABC
No. 12 Georgia Tech at Duke (-1.5), 61 | 12 pm | ESPN
No. 13 Notre Dame (-9) vs No. 20 USC, 62 | 7:30 pm | NBC
No. 14 Oklahoma (-5) at South Carolina, 43 | 12:45 pm | SEC Network
No. 15 BYU vs. No. 23 Utah (-3.5), 49 | 8 pm | FOX
No. 16 Missouri (-2) at Auburn, 43.5 | 7:45 pm | ESPN
No. 18 Virginia (-17) vs Washington State 56.5 | 6:30 pm | CW Network
No. 19 South Florida (-21.5) vs Florida Atlantic, 72.5 | 7:30 pm | ESPN2
No. 21 Texas (-12.5) at Kentucky, 42.5 |  pm | ESPN
No. 22 Memphis (-21.5) at UAB, 64 | 4 pm, ESPN2
No. 24 Cincinnati (-21.5) at Oklahoma State, 58 | 7:30 pm Friday | ESPN2
No. 25 Nebraska (-7.5) at Minnesota, 46.5 | 8 pm | FOX

See my college football 2025 Week 8 coverage at OSGA for more Top 25 game analysis, picks and opinions with information you can bet on.

Any additional updates on Saturday morning.

Picks: Tennesee, Washington
Opinions: USC and Over, MISS/GEO Under, WSH/MICH Under.

USC cashed in as our top pick in Week 7 and we’re riding the Trojans again in South Bend this Saturday. Late week and many big line moves and can’t add now including SMU from +10 to +5 at Clemson, a rematch of last year’s ACC Championship Game.

Last week’s non-Top 25 winners on Air Force (+7) and Over in UNLV’s 51-48 win sailed over in a shootout as UNLV (6-0) held on to remain undefeated. Now the Rebels have a Mountain West Conference Championship Game rematch with Boise State this Saturday, and UNLV (+13) is a big double-digit underdog.

Two games of interest and opinions on Friday include underdogs Minnesota (+7) at home and San Jose State (+4) at Utah State.