College Football 2025 Week 7 Top 25 Preview And Picks

What an upset last Saturday in college football Week 6. Winless UCLA (+24) took down top-10 Penn State 42-37 to knock the Nittany Lions out of the Top 25. The preseason No. 2 Penn State joins preseason No. 1 Texas both out of the AP Top 25 entering Week 7, which I updates with matchups, odds, picks and information you can bet on below and initially at Off Shore Gaming Association.

Three Top 25 matchups on Saturday, Oct. 11 including the Big Ten battle between top-10 teams, Indiana at Oregon. Those two powerhouses also feature elite offensive profiles with stats supporting strong, balanced offenses, which I update this week at OSGA.

Top 25 Games and Week 7 Odds

Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites plus game totals. All times ET. Top 25 matchups in bold.

Check back by Friday each week as we add more and Picks and
Opinions with select analysis, stats and information you can bet on. Early week picks posted at OSGA and added here.

Saturday, Oct. 11

(One Top 25 team playing Friday, No. 24 South Florida)

No. 1 Ohio State (-15.5) at No. 17 Illinois, 50 | 12 pm | FOX
No. 2 Miami | Bye
No. 3 Oregon (-7.5) vs No. 7 Indiana, 54.5 | 3:30 pm | CBS
No. No. 4 Ole Miss (-32) vs Washington State, 59 | 12:45 pm | SEC Network
No. 5 Texas A&M (-8.5) vs Florida, 46 | 7 pm | ESPN
No. 6 Oklahoma vs Texas (-3), 42.5 (Dallas) | 3:30 pm | ABC
No. 8 Alabama (-3.5) at No. 14 Missouri, 53 | 12 pm | CBS
No. 9 Texas Tech (-14.5) vs Kansas , 60.5 | 7:30 pm | FOX
No. 10 Georgia (-3.5) at Auburn, 46.5 | 7:30 pm | ABC
No. 11 LSU (-10) vs South Carolina, 45 | 7:45 pm | SEC Netword
No. 12 Tennessee (-13.5) vs Arkansas, 69 | 4:15 pm | SEC Network
No. 13 Georgia Tech (-14.5) vs Virginia Tech, 55.5 | 3:30 pm | ACC Network
No. 15 Michigan at USC (-2.5), 56 | 7:30 pm | NBC
No. 16 Notre Dame (-22.5) vs NC State, 62.5 | 3:30 pm | Peacock
No. 18 BYU (-2.5) at Arizona, 47.5 | 8 pm | ESPN2
No. 19 Virginia | Bye
No. 20 Vanderbilt | Bye
No. 21 Arizona State at Utah (-5.5), 49 | 10:15 pm | ESPN
No. 22 Iowa State (-5) at Colorado, 52 | 3:30 pm, ESPN
No. 23 Memphis | Bye
No. 24 South Florida at North Texas (-2.5), 66.5 | 7:30 pm Friday | ESPN2
No. 25 Florida State (-9.5) vs Pittsburgh, 58 | 12 pm | ESPN

Other teams receiving votes: Cincinnati, Texas, Penn State, Utah, Nebraska, USC, UNLV, North Texas, TCU, Washington, Mississippi State, Navy, Louisville, Auburn.

Other notable games on Sat., Oct. 4

– Northwestern at Penn State (-22), 48
– Iowa (-4) at Wisconsin, 37
– Nebraska (-5.5) at Maryland, 47
– Clemson (-14) at Boston College, 54
– Air Force at UNLV (-7), 67.5

Teams scoring at least 40 points per game, FBS opponents only: USC (48.4), Tennessee (45.8), Texas Tech (44.0), Oregon (43.5), North Texas (43.3), Vanderbilt (42.8), Indiana (41.5), Missouri (41.3), Notre Dame (40.8), Virginia (40.6), Ole Miss (40.6). Next teams > 35 ppg, Memphis, Florida State, Nebraska, Alabama, Georgia, Pitt, TCU, Penn State, Baylor, UNLV.

College Football Week 7 Picks

Picks: USC

Opinions: Illinois +, Indiana/Oregon Over

Non-Top 25
Opinions: Air Force (+6.5 / 7) and Over 65.5

Texas-Oklahoma – See OSGA.