NCAA Tournament 2025 Sweet Sixteen Betting Preview And March Madness Matchups

March Madness has played to more form for the second straight year as just one longshot has made the Sweet Sixteen – No. 10 Arkansas, one of seven remaining Southeastern Conference teams from a record 14 SEC teams that made the NCAA Tournament 2025 field. All four No. 1 seeds remain with Duke and Florida in the East and West regions plus No. 2 Alabama. In the South and Midwest regions, Auburn and Houston are alive along with No. 2’s Michigan State and Tennessee.

Those top No. 1 seeds are matched up against three No. 4 seeds – Arizona, Maryland, Purdue and No. 5 Michigan.

I provide more 2025 Sweet Sixteen matchups, betting lines, picks and updated NCAA men’s basketball championship odds in my NCAA Tournament coverage in Forbes.

I add more Sweet Sixteen coverage in OSGA, along with tips and trends with top teams stats and scoring margins.

Last year I was featured in CBS News for Sweet Sixteen and NCAA Tournament betting coverage. They had me scheduled this year but had a last second change.

Check out all the coverage for additional details, updates and information you can bet on. Select picks coming Thursday, and any for the Elite Eight over the weekend.

Last year I posted, picked and bet three Sweet 16 winners (3-0).

NCAA Tournament – Updated Bracket, Schedules and Scores

 

2025 Sweet Sixteen Match-ups and Odds

Betting lines, odds and over/under game totals by region courtesy of Caesars Sportsbook. Odds are subject to change. All times Eastern. 

Thursday, March 27

East – Prudential Center (Newark, NJ)

– No. 6 BYU vs. No. 2 Alabama (-5.5)| Total 175.5 | 7:09 p.m. | CBS
– No. 4 Arizona vs. No. 1 Duke (-9)| Total 153.5| 9:39 p.m. | CBS

West – Chase Center (San Francisco, CA)

– No. 4 Maryland vs. No. 1 Florida (-6) | Total 157.5 | 7:39 p.m. | TBS
– No. 10 Arkansas vs. No. 3 Texas Tech (-5.5) | Total 148 | 10:09 p.m. | TBS

Friday, March 28 

South – State Farm Arena (Atlanta, GA)

– No. 6 Ole Miss vs. No. 2 Michigan State (-3.5) | Total 143.5| 7:09 p.m. | CBS
– No. 5 Michigan vs. No. 1 Auburn (-9) | Total 153.5 | 9:39 p.m. | CBS

Midwest – Lucas Oil Stadium, (Indianapolis, IN)

– No. 3 Kentucky vs. No. 2 Tennessee (-4.5) | Total 144.5 | 7:09 p.m. | TBS
– No. 4 Purdue vs. No. 1 Houston (-8) | Total 132 | 10:39 p.m| TBS

Duke, Auburn, Houston and Florida also the four teams rated 1-4 in the current NET rankings. Those four teams along with Tennessee rank top-20 in both adjusted offensive and defensive efficiency ratings, per KenPom.

And 21 of the last 22 national champions have ranked top-20 in both adjusted offensive and defensive efficiency.

Those teams rankings and adjusted odds to win national championship.

• +220: Duke (No. 1 offense, No. 4 defense)
• +375: Florida (2,10)
• +475: Auburn (3,12)
• +500: Houston (10,1)
• +1800: Tennessee (17,3)

More updates, picks and information you can bet on as the Sweet Sixteen and Elite Eight play out this weekend on the Road to the Final Four in San Antonio.