NCAA Tournament 2025 Stats And Profiles: No. 1 and No. 2 Seeds South And Midwest Regions

March Madness is set to tipoff and the 2025 NCAA Tournament is set for record wagering. The biggest line moves in the opening round are drawing attention on bigger underdogs, and a record 14 SEC teams are in the NCAA Tournament 2025 event looking to make a run to the Final Four. I’ve outlined the stats and profiles for the top teams in my coverage for OSGA, which follows the conference tournaments. The No. 1 and No. 2 seeds in the East and West regions will be popular picks to reach the Final Four and cut down the nets. Duke and Florida are top seeds and favorites to win this year’s national championship and run through the brackets, while Alabama‘s nation-best scoring and Big East bruiser St. John’s are also teams drawing interest with solid NCAA Tournament 2025 stats.

Check out the stats and profiles, including No. 1 and No. 2 seeds in the South and Midwest regions with Auburn and Houston leading the way. Fellow defensive dominator Tennessee along with the Big Ten’s best in Michigan State try to get through the brackets and make the Final Four in San Antonio.

A previous season keys to NCAA Tournament success may also assist you in your pursuit of profit when wagering on college basketball and March Madness.

Key stats to picking an NCAA Tournament champion

When evaluating the KenPom advanced stats, know that 21 of the last 22 National Champions have finished in the Top 20 in both offensive and defensive adjusted efficiency. This year’s top teams in NCAA Tournament 2025 stats include:

– Florida (1 offense, 10 defense)
– Auburn (2,12)
– Tennessee (18,3)
– Duke (3,4) from ACC
– Houston (10,2) from Big 12
– Iowa State (20,9) from Big 12

Three SEC teams top the charts with more stats and streaks outlined in my March Madness coverage in Forbes as a record 14 SEC teams selected for 2025 NCAA Tournament.

Keys to NCAA Tournament success

Other teams and top-5 seeds to watch and their offensive/defensive stats profiles include:

– Alabama (4,32), St. John’s (65,1), Michigan State (27,5), Texas Tech (6,37), Wisconsin (13,27), Kentucky (8, 56), Texas A&M (44,7), Maryland (6,56), Arizona (12,33), Purdue (7,63), Clemson (24,16), Oregon (39,31) Michigan (47,14), Memphis (72,40) and somehow low 8-seed Gonzaga (9,29) with 2-time defending national champion Connecticut (14,94) also an 8-seed.

NCAA Tournament Top 50 Players

As you review more March Madness matchups and make your bets, check back ahead of and during the NCAA Tournament for more content, stats, odds updates from leading online sportsbooks with information you can bet on.

No. 1 and No. 2 Seeds South Region

No. 1 Auburn Tigers

Record: 28-5
Key Wins: Houston (N), Iowa State (N), North Carolina (N), Memphis (N), Purdue (N), at Kentucky, at Alabama, Ole Miss (3x), Tennessee, Georgia, Missouri
Key Losses: at Duke, at Texas A&M, Florida, Alabama, Tennessee (N)
National Title Odds: +500
Final Four Odds: +100
KenPom Strength of Schedule: 2
KenPom Stats: Adjusted Offense No. 2, Defense No. 12
X: @Auburn MBB
Head Coach: Bruce Pearl

Auburn’s 16 Quad 1 wins were most in the country. The Tigers efficient offense ranks No. 2 and 3-point FG defense (29.2%) is top-5 along with shot blocking. Power forward Johni Broome is one of the top-3 players in the tournament and up for Player of the Year honors. Auburn is one of seven teams in the tournament with a scoring margin of +14 points per game or better. The Tigers are also a defensive dominator and one of six teams in the country that rank top-20 in both offensive and defensive efficiency – which has produced 21 of the past 22 national champions.

No. 2 Michigan State Spartans

Record: 27-6
Key Wins: North Carolina (N), Illinois (2x), Michigan (2x), Oregon (2x), Purdue, at Maryland
Key Losses: Kansas (N), Memphis (N), Wisconsin (N), at UCLA
National Title Odds: +1800
Final Four Odds: +450
KenPom Strength of Schedule: 27
KenPom Stats: Adjusted Offense No. 27, Defense No. 5
X: @MSU_Basketball
Head Coach: Tom Izzo

Michigan State won the Big Ten regular season title, and like Auburn, was eliminated in the conference tournament semi’s. The Spartans had 13 Quad 1 wins and are once again a top-tier defense ranking top-5 in adjusted efficiency, elite 3-point defense (27.9%) and rebounding. The Spartans take a low-percentage of 3-point shots but are among the worst 3-point shooting teams (30.8%). Guard Jase Richardson has provided late season strength scoring 20+ points in six of the final seven games with Sparty winning 8-straight until losing to Wisconsin in the Big Ten tourney. Michigan State’s 21 ATS wins is tops in the tournament.

No. 1 and No. 2 Seeds Midwest Region

No. 1 Houston Cougars

Record: 30-4
Key Wins: Kansas (2x), at Arizona, at Texas Tech, Baylor (2x), Iowa State
Key Losses: Auburn (N), Alabama (N), Texas Tech
National Title Odds: +600
Final Four Odds: +130
KenPom Strength of Schedule: 24
KenPom Stats: Adjusted Offense No. 10, Defense No. 2
X: @UHCougarMBK
Head Coach: Kelvin Sampson

Houston had 14 Quad 1 wins, but lost to both Alabama and Auburn. The Cougars elite defense is No. 2 in adjusted efficiency, top-5 in adjusted FG% defense (44.9) and 2-point defense (43.9). This year Houston’s offense is better, ranking top-10 in adjusted efficiency, top-5 in 3-point shooting (39.8%) and top 10 in blocks with guard L.J. Cryer’s strong 3-point (43%) and free throw (91%) shooting.

No. 2 Tennessee Volunteers

Record: 30-4
Key Wins: Auburn (N), Baylor (N), Texas (N), at Illinois, at Louisville, at Oklahoma, at Texas A&M, Florida, Alabama, Missouri
Key Losses: Florida (2x), Kentucky (2x), at Auburn, at Ole Miss, at Vanderbilt
National Title Odds: +2200
Final Four Odds: +325
KenPom Strength of Schedule: 6
KenPom Stats: Adjusted Offense No. 18, Defense No. 3
X: @Vol_Hoops
Head Coach: Rick Barnes

Tennessee is another defensive dominator who ranks top-3 in adjusted defensive efficiency, effective FG% defense (44.4), and No. 1 in 3-point defense (27.8%) and top-5 in blocks percentage. Coach Barnes has an experienced team and relies heavily on his starters with diminutive guard Zakai Zeigler the heart-and-soul of the Vols as an elite playmaker and among a number of top defenders.

More updates and information you can bet on during the 2025 NCAA Tournament.

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