2025 NFL Week 16 Tips, Totals, Teasers And Trends

The final three weeks of the pro football season will determine playoff positions for the top teams battling for a postseaon berth. That includes the Los Angeles Rams (11-3) and Seattle Seahawks (11-3), who kickoff NFL Week 16 tips, totals and teasers in my weekly coverage at OSGA.

Check out the injury reports and monitor the NFL weather as you make your bets each week and for the 2025 NFL Week 16 tips, totals and teasers.

NFL Week 16 Odds

Betting lines and NFL odds from top online sportsbooks refresh periodically and are subject to change, including on props and live/in-game betting. Point spread on favorites and division games in bold for 2025 NFL Week 16 tips.

Point spread on favorites and division games in bold.

– Los Angeles Rams (-1) at Seattle, 44  – Thursday
– Philadelphia (-6.5) at Washington, 44.5 – Sat.
– Green Bay (-1.5) at Chicago, 47 – Sat.
– Buffalo (-10) at Cleveland, 42.5
– New York Jets at New Orleans (-4.5), 40
– Minnesota (-3) at New York Giants, 43.5
– Tampa Bay (-3) at Carolina, 45
– Kansas City (-3.5) at Tennessee, 37.5
– Los Angeles Chargers at Dallas (-2), 49.5
– Cincinnati (-1.5) at Miami, 50.5
– Atlanta (-2.5) at Arizona, 48
– Jacksonville at Denver (-3), 46
– Pittsburgh at Detroit (-7), 51
– Las Vegas at Houston (-14), 38.5
– New England at Baltimore (-3), 48 – SNF
– San Francisco (-6) at Indianapolis, 46.5 – MNF

Week 16 Game Totals

Eagles-Commanders – Over (added Wed)

Opinions

Rams-Seahawks – Under
Bills-Browns – Under
Jaguars-Broncos – Over
Steelers-Lions – Over

Check back for more Friday, including any upgrades along with Week 16 picks, props and parlays that are 7-2 on picks since Week 11 following the Week 15 pick on the Steelers in their MNF win over the Dolphins.

Teasers

– Seahawks, Bears, Chargers, Panthers, Dolphins

Additional playoff probabilities and information you can bet on in my coverage at OSGA.

You can bet on it.