College Football 2025 Week 6 Top 25 Preview And Picks
October football has arrived, and who would believe the marquee matchup in college football 2025 Week 6 would be Vanderbilt at Alabama? Two top-20 teams and the ‘Tide playing with redepmption for last year’s loss to the ‘Dores, 40-35 as a 24-point favorite! Top 25 college football Week 6 coverage, picks, and more details and analysis in my weekly coverage at Off Shore Gaming Association.
Poor Week 5 college football picks and opinions in Top 25 action, which followed a 9-2 ATS run in Week 2 and Week 3.
Top 25 Games and Week 6 Odds
Betting lines and college football odds from top online sportsbooks refresh periodically and are subject to change, including on props and live betting. Current point spread on favorites plus game totals. All times ET for college football 2025 Week 6.
Check back by Friday each week and Saturday morning as we add more Picks and Opinions with select analysis, stats and information you can bet on.
Saturday, Oct. 4
(One Top 25 team playing Friday, BYU)
No. 1 Ohio State (-24) vs. Minnesota, 44.5 | 7:30 pm | NBC
No. 2 Oregon | Bye
No. 3 Miami (-4.5) at No. 18 Florida State, 53.5 | 7:30 pm | ABC
No. 4 Ole Miss | Bye
No. 5 Oklahoma (-45.5) vs. Kent, 53.5 | 4 pm | SEC Network
No. 6 Texas A&M (-14) vs. Mississippi State, 55.5 | 7:30 pm | SEC Network
No. 7 Penn State (-25.5) at UCLA, 50.5 | 3:30 pm | CBS
No. 8 Indiana | Bye
No. 9 Texas (-7) at Florida, 42 | 3:30 pm | ESPN
No. 10 Alabama (-11.5) vs. No. 16 Vanderbilt, 55.5 | 3:30 pm | ABC
No. 11 Texas Tech (-11) at Houston, 51 | 7 pm | ESPN
No. 12 Georgia (-20.5) vs. Kentucky, 48.5 | 12 pm | ABC
No. 13 LSU | Bye
No. 14 Iowa State at Cincinnati (-2), 54 | 12 pm | ESPN2
No. 15 Tennessee | Bye
No. 17 Georgia Tech | Bye
No. 19 Missouri | Bye
No. 20 Michigan (-17) vs. Wisconsin, 42.5 | 12 pm | FOX
No. 21 Notre Dame (-20.5) vs. Boise State, 62.5 | 3:30 pm | NBC
No. 22 Illinois (-10) at Purdue, 57 | 12 pm | Big Ten Network
No. 23 BYU (-18.5) vs. West Virginia, 47 | 10:30 pm Friday, ESPN
No. 24 Virginia at Louisville (-7), 61.5 | 3:30 pm | ESPN2
No. 25 Arizona State | Bye
College Football Top 25 Picks
See other games, analysis and picks at OSGA.
Opinions: Vanderbilt, Florida State
Non-Top 25
Pick: Louisiana Monroe (+11.5) at Northwestern
Opinion: Wyoming (+3.5) vs. UNLV (weather)
Little watch and wager interest in the ULM-Northwestern game, but that’s a mistake with the Wildcats (2-2) laying big chalk averaging just 11.3 points per game (130th) and 288 yards per game. Too much credit for the Wildcats 17-14 win last week over UCLA with even yardage near 300, and NW has Penn State on deck. UL Monroe (3-1) lost to Alabama 73-0. That’s sticks in bettors minds, but what a majority doesn’t know is that the Warhawks have a +141 run advantage and a +1.3 net yards per play edge vs. Northwestern after ULM outrushed Arkansas State 199-12 last week in a 28-16 win. Your big ‘Dog of the day winner on the Warhawks.
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